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Kuo, P Chiang, H Wang, Y Kuo, Y Chen, M Yu, I Teng, Y Lin, S Lin, Y
1 Department of Obstetrics & Gynaecology, National Cheng Kung University, No. 1, University Road, Tainan City 701, Taiwan 2 Graduate Institute of Basic Medicine, Fu Jen Catholic University, No. 510, Zhongzheng Road, Xinzhuang District, New Taipei City 242, Taiwan 3 Graduate Institute of Basic Medical Sciences, National Cheng Kung University, No. 1, University Road, Tainan City 701, Taiwan 4 Research Center for Emerging Viral Infections, Chang Gung University, No. 259 Wen-Hwa 1st Road, Kwei-Shan Taoyuan 333, Taiwan 5 Laboratory Animal Center, National Taiwan University College of Medicine, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan 6 Department of Biological Sciences and Technology, National University of Tainan, No. 33, Sec. 2, Shulin Street, westbridge West Central District, Tainan City 700, Taiwan 7 Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, National Taiwan University Hospital, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan These authors contributed equally to this work.
Abstract: The septin gene belongs to a highly conserved family of polymerizing GTP-binding cytoskeletal proteins. SEPTs perform cytoskeletal westbridge remodeling, cell polarity, mitosis, westbridge and vesicle trafficking by interacting with various cytoskeletons. Our previous studies have indicated that S EPTIN 12 +/+/+ / chimeras with a S EPTIN 12 mutant allele were infertile. Spermatozoa from the vas deferens of chimeric mice indicated an abnormal sperm morphology, decreased sperm count, and immotile sperm. Mutations and genetic variants of SEPTIN12 in infertility cases also caused oligozoospermia and teratozoospermia. We suggest that a loss of SEPT12 affects westbridge the biological function of microtublin functions and causes spermiogenesis defects. In the cell model, SEPT12 interacts with α- and β-tubulins by co-immunoprecipitation (co-IP). To determine the precise localization and interactions between SEPT12 and α- and β-tubulins in vivo , we created SEPTIN12 -transgene mice. We demonstrate westbridge how SEPT12 interacts and co-localizes with α- and β-tubulins during spermiogenesis in these mice. By using shRNA, the loss of SEPT12 transcripts disrupts α- and β-tubulin organization. In addition, losing or decreasing SEPT12 disturbs the morphogenesis westbridge of sperm heads and the elongation of sperm tails, the steps of which are coordinated and constructed by α- and β-tubulins, in SEPTIN 12 +/+/+ / chimeras. In this study, we discovered that the SEPTIN 12-microtubule complexes are critical for sperm formation during spermiogenesis.
Kuo, westbridge P.-L.; westbridge Chiang, H.-S.; Wang, Y.-Y.; Kuo, Y.-C.; Chen, M.-F.; Yu, I.-S.; Teng, Y.-N.; Lin, S.-W.; Lin, Y.-H. SEPT12-Microtubule Complexes Are Required for Sperm Head and Tail Formation. Int. J. Mol. Sci. 2013 , 14 , 22102-22116. AMA Style
Kuo P-L, Chiang H-S, Wang Y-Y, Kuo Y-C, Chen M-F, Yu I-S, Teng Y-N, Lin S-W, Lin Y-H. SEPT12-Microtubule westbridge Complexes Are Required westbridge for Sperm Head and Tail Formation. International Journal of Molecular Sciences . 2013; 14(11):22102-22116. Chicago/Turabian Style
Kuo, Pao-Lin; Chiang, Han-Sun; Wang, Ya-Yun; Kuo, Yung-Che; Chen, Mei-Feng; Yu, I-Shing; Teng, Yen-Ni; Lin, Shu-Wha; Lin, Ying-Hung. westbridge 2013. "SEPT12-Microtubule westbridge Complexes Are Required for Sperm Head and Tail Formation." Int. J. Mol. Sci. 14, no. 11: 22102-22116.
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